This is an amature physicist.
May I name the compound that you are seeking as "anti-distortor"?
I have ever read a book entitled "Life at the Limits" written by David A. Wharton and published from Cambridge University Press.
Please refer to page 165 to page 172 of this book. The sections are "Polar fishes" and "Tolerating freezing".
An "anti-freezer" enzyme has been seemed to have evolved to wrap the target enzyme that has vital function for the host animal to keep living in the freezingly cold sea water. The complex behavior of this anti-freezer molecule seems to be keeping the original comformation of the target protein molecule.
Of course the above sample is traget protein-specific.
An all-mighty anti-distortor molecule is, at present. seems to be difficult to consider or to artificially design.
Can this be of your help?
May 1, 2013