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Is it possible to chemically inhibit conformational changes in chemical structures of proteins?

Question asked by Kim Blenman on Nov 13, 2009
Latest reply on May 1, 2013 by Mitsuru Yamada

Dear Group


It has been quite a while since I have focused on basic chemistry and am currently trying to get back into the area. Since it has been so long, I must disclose that I have reverted into a newbie. With that being said, please bear with me if my question seems naïve. I am interested in finding chemical compounds that can prevent conformational changes in the chemical structures of proteins. In essence, I would like to make the chemical structures completely rigid. The idea is to keep the structures in the original conformation that they are collected in. I prefer to stay away from cross-linking compounds like aldehydes since the mechanisms of formation of the cross-links alter the conformation of the proteins from their original state. I also prefer to stay away from alcohols since the dehydrating property also alters the conformation of proteins. These preferences limit my options quite considerably. I am not quite sure where to go from here. Does anyone have any suggestions of other types of chemical compounds that could be used to inhibit conformational changes in the chemical structures of proteins?