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Is it possible the Schiff Base reaction happen by reacting a compound containing an amine group and a sulfonic acid group (-SO3H) with an aldehyde?   Will the sulfonic acid group gives any effect to the amine side to react with the carbonyl from aldehyde?

Question asked by Choon Wan Yeap on Sep 24, 2013

Is it possible the Schiff Base reaction happen by reacting a compound containing an amine group and a sulfonic acid group (-SO3H) with an aldehyde?

Will the sulfonic acid group gives any effect to the amine side to react with the carbonyl from aldehyde?

In this case, which the compound is not really soluble in non polar solvent such as ethanol, chloroform, DCM and others. And if I run in DMSO, it will be harder to remove the water from it and also the DMSO solvent. Any suggestion for the solvent use?

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