Alex Dean

T-705 (Favipiravir) inhibits in vitro norovirus replication

Discussion created by Alex Dean on Dec 24, 2017

T-705 (favipiravir) is an antiviral molecule that is being developed for the treatment of influenza virus infections but that exerts also activity against a number of unrelated RNA viruses, including bunyaviruses, arenaviruses and flaviviruses. T-705 is converted to its active form T-705 ribofuranosyl 5’-tri-phosphate by cellular enzymes. This metabolite inhibits the influenza polymerase without affecting the synthesis of cellular RNA and DNA.