Alex Dean

DNA-Encoded Library Technology

Discussion created by Alex Dean on Apr 26, 2018

DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type collections of combinatorial organic molecules, individually coupled to distinctive DNA fragments.

 

Biological selection methods has largely relied on the expression and screening of peptides and proteins that are encoded by DNA and expressed by a cell, so biology-based drug discovery facilitate the construction and screening of libraries containing billions of polypeptides.

Outcomes