DNA encoded library (DEL) is a new screening platform commonly used to discover small-molecules that interfere with the activity of pharmaceutically relevant proteins. DNA-encoded chemical libraries are hybrid-type collections of combinatorial organic molecules, individually coupled to distinctive DNA fragments.
The discovery of a novel drug is usually a multi-phase process, and one of central steps in drug discovery is the identification of binding molecules to protein targets of pharmaceutical interest. Some methods including high-throughput screening (HTS), fragment-based drug discovery, and computer-assisted drug discovery are available for early drug hit discovery. The molecular diversity and quality of the screening collection can be crucial in using HTS to discover compounds having desirable pharmacological properties.