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Alex Dean
t is a strange phenomenon that there is an increasing fondness for natural stuff, in particular, food and cosmetic products produced from natural sources without added artificial ingredients. In this sense, natural products usually refer to purified organic compounds isolated from natural sources.   Natural compounds receive world
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Alex Dean
A total synthesis of maytansinol (1) was achieved, in a convergent way, using (3S,6S,7S)-aldehyde 4 and (S)-p-tolyl sulfoxide 3 as fragments. When the anion of 3 was condensed with aldehyde 4, some induction at C(10) was observed (60% de), giving the C(1)-N(19)-open-chain compound 7, after thermal elimination of sulfinate. Pure E/E stereochemistry
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Alex Dean
Substances related to temocillin and products formed by degradation of it in acid and alkali were chromatographed to investigate the specificity of the method. The related substances examined and their retention times are given in this paper. Degradation studies were carried out on solutions containing about 5 mg ml-1 of temocillin in 0.1 M sodium
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Alex Dean
A remarkable increase of multidrug-resistant bacteria has become a serious threat to public health threat. The amphiphilic antibiotics that attack bacterial membranes are promising agents for combating bacterial pathogens. Among them, cyclic decapeptide gramicidin S (GS), cyclo(-Val-Orn-Leu-D-Phe-Pro)2, are attractive targets for drug discovery.
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