Medicinal Chemistry in Animal Health and the Unique Challenges Dr. Matthew Bedore Zoetis, Inc. Medicinal chemistry in human health is a well-documented discipline but the challenges facing an animal health medicinal chemist are often less known and can vary from their human health counterpart. One such example is in heartworm (Dirofilaria immitis) prevention in companion animals which is becoming increasingly problematic due to developing resistance against current macrocyclic lactone (ML) treatments. In order to combat resistance, new substrate is being sought to achieve HW prevention. Depsipeptides, such as emodepside, represent an exciting class of molecules which have shown efficacy against ML resistant heartworm strains in dogs. Initial structure-activity relationship development and navigation of complex synthetic challenges led to the identification of new depsipeptides with improved in vitro potency and larval stage selectivity over emodepside. The unique challenges of this class of compounds for treating canine heartworm disease and the overall differences in early discovery for animal health will be discussed from a medicinal chemistry perspective.
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Next Section Meeting Date: Thursday, April 20 Time: 7:00 pm (light refreshments will be available at 6:30pm) Location: Auditorium, B‐86 Eastman Chemical Company Longview, TX
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Speaker: Dr. Charles Whiteside Topic: History of Ana-Lab Date: Thursday, September 22, 2022 Time: 7:00 pm (6:30 pm for refreshments) Location: Ballroom in the Duvall Student Center Kilgore College Address: 726 Nolen Ave. Kilgore, TX 75662
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We will have a student poster session at UT-Tyler on April 21, 2022 at 7pm. Join us as we network with students and discuss their research. If you or one of your students, would like to present, please contact Sean Butler (sbutler@uttyler.edu) by April 14. Newsletter is attached with more information.
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Information regarding the next meeting of the East Texas Section and the March newsletter has been posted on this site. Newsletter also contains information regarding upcoming events.
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