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Alex Dean
Favipiravir (T-705) is a nucleoside analog that was recently approved as an anti-influenza drug in Japan, and is in Phase 3 clinical trials in the USA for the same indication. It is active against a growing list of virulent RNA viruses including Ebola virus, and the author studies show that it is highly protective in rodent models of Argentine
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Alex Dean
Tailor-made enzymes with modified activity and the preparation of thermostable and pH stable enzymes produced by random and site-directed mutagenesis have lead to the production of novel stereoselective biocatalysts. The use of enzymes in organic solvents has led to hundreds of publications on enzyme-catalyzed asymmetric synthesis and resolution
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Alex Dean
The yields of epothilone D (I) in the synthesis we developed in the longest linear successions of 23 stages proceeding from diethyl adipate and 24 stages, from (R)-methyl 2,3-О-isopropylidene glycerate (XX) were 2 and 1.6% respectively. It is close to the average number of stages and overall yield (2.3%) in the previously described approaches. The
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