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Sam1
New Contributor

Ions release from Nanoparticles

How are metal ions released from nanoparticles (designed to act as antimicrobials) capped/stabilized with other agents??

P.S-please explain to me assuming i'm a non-chemistry major

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Alexmadonik
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Re: Ions release from Nanoparticles

Sam,

As I expect you know, it's a general characteristic of metals that they form positive ions when exposed to oxygen.  This is the oxidiation process that causes iron to rust.  It's slower with silver (the most familiar antimicrobial nanoparticle), but Ag+ ions will form on any silver surface exposed to air.  What's more, it turns out bacterial cell walls are negatively charged, so they stick to silver nanoparticles (presumably displacing any stabilizing groups that may be present in the silver nanoparticle preparation).  This binding process may disrupt the cell wall, or allow toxic silver ions or reactive oxygen species to enter the cell.  You can read more about these processes here:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075170/ 

Nanomaterials (Basel). 2020 Feb; 10(2): 292.
Published online 2020 Feb 9. doi: 10.3390/nano10020292
PMCID: PMC7075170
PMID: 32050443

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

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