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Questions about painkillers

Are most painkillers produced from synthetic sources or can many be made from natural sources like opium?

How expensive is the production of paracetamol and does the painkiller market have to be subsidised?

What types of conditions are typically used to manufacture painkillers?

Is there a reason that most painkillers have a benzene ring in their structure?

Do different functional groups determine the effects of different painkillers?

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