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Gastric Inhibitory Polypeptide

Gastric inhibitory peptide (GIP) is a member of the secretin family of hormones. It was discovered as a factor in extracts of intestine that inhibited gastric motility and secretion of acid, and initially called enterogastrone. Like secretin, it is secreted from mucosal epithelial cells in the first part of the small intestine.

Another activity of GIP is its ability to enhance the release of insulin in response to infusions of glucose. For this action, it has also been referred to as glucose-dependent insulinotropic peptide.

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