Name:
David R Weyna
Country:
USA
City:
Nashville
State/Province:
IN
ACS Member:
Non-member
Local Section:
International Chapter:
Technical Division Membership:
Technical Division Membership Emeritus:
Subdivision Member:
ACS Activities:
SERMACS 2006 Poster:
Co-Crystals and Polymorphism of Aspirin
David R. Weyna and Michael Zaworotko
, SERMACS 2007 Talk
15. Multiple Component Crystal Forms of Active Pharmaceutical Ingredients
David R. Weyna and Mike J. Zaworotko, University of South Florida, Tampa, FL
Active pharmaceutical ingredients (APIs) have different physiochemical properties depending on which
crystal form they adopt, thereby justifying application of the concepts crystal engineering to APIs.
Cocrystals, multiple component salts, and solvates all provide a new
avenue for pharmaceutical development and a way to improve currently marketed pharmaceuticals that
are in need for improvement due to solubility, bioavailability, and/or stability issues. Synthesis and
structural information on novel crystal forms where at least one component is an API will be discussed
including the following:
Bicalutamide•4,4'-Bipyridine, Bicalutamide•trans-1,2-bis(4-pyridyl)ethylene, Naproxen•trans-1,2-bis(4-
pyridyl)ethylene, Baclofen•H2O, Baclofen•4-Chlorobenzenesulfonic acid•H2O, Baclofen•p-
Phenolsulfonic acid•H2O, Baclofen•Ethanesulfonic acid, and Aspirin•4,4'-Bipyridine.
Company/Institution Name:
Career Stage:
Retired
Research and Special Interests:
Discovery of multiple component crystal forms to manipulate the physicochemical properties of interest with cocrystals as the main focus.
Area of Expertise:
Supramolecular Chemistry, Preformulation, Drug Delivery
Years of Expertise:
1-5