Upcoming Webinars

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Upcoming Webinars

The importance of glucuronidation for metabolism of xenobiotics in humans is illustrated by the abundance and broad tissue distribution of the enzymes, the diversity of substrates and reactions catalyzed, and the number of distinctive UGT enzymes and their genetic polymorphisms.   The involvement of UGTs in metabolism of new drug candidates will be presented as it underscores the enzymes’ importance from regulatory and safety perspectives. Basic biochemical characteristics of UGTs will be reviewed and examples of major forms of glucuronides formed in humans will be presented. Distinctive properties of acyl-glucuronides and their significance for drug-drug interactions will be highlighted. Factors contributing to underprediction of UGTs’ in vivo contributions to the metabolism of xenobiotics will also be covered. Laboratory approaches aimed at improving these predictions will be covered, as well.   Key Learning Objectives: Significance of UGT-mediated metabolism in drug development process Consequences of formation of acyl-glucuronides Underprediction of in vivo UGT-mediated metabolism Who Should Attend: Research scientists and drug development leadership aiming for successful IND / NDA submission, needing to meet regulatory requests and expectations, desiring to formulate a development plan that mitigates risks of late-stage failure, or simply wanting to better understand the ADME properties and potential DDI risks of their compound. Brought to you by: Speakers: Maciej Czerwinski, Ph.D. Director of Scientific Consulting, XenoTech Kelly McSweeney Contributing Editor, C&EN Media Group
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IR and Raman spectroscopy are well established, mature techniques present nowadays in most analytical laboratories.  However, they do pose several key fundamental limitations. The new breakthrough technique of Sub-micron Optical Photothermal Infrared (O-PTIR) Spectroscopy overcomes the limited spatial resolution of traditional IR microscopy with submicron resolution and the limited sensitivity and fluorescence interference limitations of Raman microscopy.    Furthermore, O-PTIR is able to bring together the complementarity of IR and Raman into a single platform, single measurement for the first time, enables sub-micron, simultaneous IR+Raman microscopy delivering IR and Raman spectra from the same spot, at the same time with the same spatial resolution.    This webinar discusses this novel technique and provides numerous application examples.   Part 1: Introduction & Overview by Dr. Mustafa Kansiz   Overview of current direct IR (FTIR & QCL) and Raman micro spectroscopic techniques and Fluorescence Microscopy  Introduction to Submicron O-PTIR and simultaneous Raman microscopy (IR+Raman) and the benefits of co-located Fluorescence  Various application examples of particulates, materials science and more   Part 2: Review of Environmental Applications by Dr. Andrew Ault Microplastics, environmental   Dr. Ault will present the results of his group's recent publication on an important source of atmospheric particles - Sea Spray Aerosols (SSA).     In this work, they characterize individual SSA particles using new generation submicron simultaneous IR+Raman (O-PTIR) microscopy for organic profiling, combined with EDX for elemental profiling.    Dr. Ault will also talk to his recent research relating to microplastics.   Key Learning Objectives: Understand the principle of operation of O-PTIR for submicron IR spectroscopy Learn about specific applications of submicron simultaneous IR and Raman  How O-PTIR can advance your research goals and increase the impact of your publications  Who Should Attend: Laboratory Directors and Managers   Research Professors and Academics Regional Water Board Researchers Industrial Failure Analysis Engineers Chemical and Polymer Engineers and Scientists Vibrational Spectroscopists   Brought to you by: Speakers: Dr. Mustafa Kansiz Director of Product Management and Marketing, Photothermal Spectroscopy Corp. Dr. Andrew Ault Dow Corning Assistant Professor of Chemistry and Associate Professor of Chemistry, University of Michigan Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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Synthetic oligonucleotides have become the fast-growing therapeutic modality in recent years and are being increasingly developed for treating a wide range of disease conditions. Along with the development of these therapeutic candidates comes the increased need for reliable analytical methods and easy-to-use data analysis workflows to fully characterize them to ensure the intended efficacy. Thus, reliable and sensitive analytical and preparative methods are required to adequately resolve impurities and establish purity and identity of the intended oligonucleotide product.   In this presentation, we will present the relevant chromatography, mass spectrometry and spectroscopy based analytical strategies to confidently detect, quantify and purify oligonucleotides and their related impurities that can help you meet both the challenges of synthetic oligonucleotide quality assessment, and the productivity needs of your lab.   Key Learning Objectives: Learn about the manufacturing challenges associated with synthetic oligo drugs Learn about the critical quality attributes for complete assessment of synthetic oligonucleotides Learn about the analytical approaches for the confident identification, quantification and purification of synthetic oligonucleotides and the related impurities Who Should Attend: Laboratory managers Chromatographers New product developers Brought to you by: Speakers: Parul Angrish, Ph.D. Director, Biopharma/Pharma Market Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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