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Upcoming Webinars

The progress in RNA-based therapies has seen significant advancements, including the approval of pioneering treatments like patisiran in 2018 and the recent development of COVID-19 vaccines using Lipid nanoparticle (LNP) formulations. Researchers have optimized the effectiveness of these therapies by leveraging electrostatic complexation of anionic RNA, utilizing a composition of cationic and ionizable lipids, combined with other lipids. High-throughput screening using robotic automation in a 96-well plate format has emerged as an efficient method, demonstrating results comparable to the current state-of-the-art methods.    To automate the LNP formulation for screening purposes, a protocol was established using the Andrew+ liquid handling platform. The method was developed to overcome challenges such as rapid evaporation of ethanolic lipid solutions. The automated method maintained consistent particle size and high mRNA encapsulation efficiency. The transfection efficiency into HepG2 cells was comparable to both manual pipetting and microfluidics based LNP preparation methods. Thus, the automated method using Andrew+ has shown promise in streamlining LNP formulation and advancing the development of mRNA-based therapies, offering high precision and repeatability for the high-throughput screening of various LNPs.    Key Learning Objectives: Preparation of mRNA loaded LNPs  Comparison of manual pipetting, automated pipetting using Andrew+ and microfluidic methods  LNP characterization and high-throughput in vitro screening  Who Should Attend: Researchers, industry laboratory heads and technicians in the field of LNP formulation or pipetting automation  Students new to the field of LNP formulation  Brought to you by: Speakers: Dr. Ryan Karongo Scientific Labhead, Drug Targeting and Vectors Team, Bayer AG Dr. Michael Karimov Research Scientist, Drug Targeting and Vectors Department, Bayer AG Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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Tuesday, March 5, 2024
Join Asst. Prof Caitlin Davis of Yale University to learn about recent research on a critical metabolic process in live cells – de novo lipogenesis, using a breakthrough new technology that enables IR spectroscopy and imaging at submicron spatial resolution on a wide range of samples including in water. The breakthrough technology that enables sub-micron IR spectroscopy is Optical Photothermal IR Spectroscopy (O-PTIR). Prof. Davis will discuss how she uses O-PTIR to probe metabolic heterogeneity in live cells with rapid sub-micron IR imaging.     In the opening part of this webinar, hear from Dr. Mustafa Kansiz (PSC), as he provides an introductory overview of O-PTIR and how it’s being used by scientists in a wide range of application areas including, life science, microplastics, pharmaceutical sub-visible particulates and contamination identification in industrial failure analysis.  Key Learning Objectives: Understand the principle of operation for submicron IR spectroscopy  Learn about specific applications of simultaneous IR and Raman  How O-PTIR can advance your research goals and increase the impact of your publications  Who Should Attend: Research Professors and Academics  Laboratory Directors and Managers   Industrial Failure Analysis Engineers Chemical and Polymer Engineers and Scientists Vibrational Spectroscopists  Brought to you by: Speakers: Prof Caitlin Davis Assistant Professor of Chemistry, Yale University       Dr. Mustafa Kansiz Director of Product Management, Photothermal Spectroscopy Corp     Alexandra Taylor Contributing Editor, C&EN Media Group  
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Wednesday, March 6, 2024
To remain competitive against other technologies, mass spectrometry (MS) needs to rise to the challenge of unprecedented throughput with very deep analyses of very complex samples. With analysis time reduced to several minutes by fast liquid separations, confident identification and quantitation over many orders of dynamic range still requires a generational leap in the sequencing performance of MS. The Thermo Scientific™ Astral™ analyzer is a novel class of high-resolution accurate-mass analyzer that compliments the Thermo Scientific™ Orbitrap™ analyzer to provide high speed and sensitivity measurements.   This webinar will explore the underlying technology of the Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer and its’ application to biomedical research. Rethink what is possible with a mass spectrometer including the analysis of 300 proteomics samples per day, measuring 5,000 proteins from a true single-cell, and collecting fragmentation data on over 90% of compounds in metabolomics experiments.   Key Learning Objectives: Learn about the novel technology of the Orbitrap Astral mass spectrometer   Understand the benefits of the Orbitrap Astral mass spectrometer   How to apply the Orbitrap Astral mass spectrometer to solve biological questions  Who Should Attend: Academic Researchers  R&D Scientists  Lab Technicians Principal Investigators Lab Managers  Brought to you by: Speakers: Dr. Alexander Makarov Director, Global Research LSMS, Thermo Fisher Scientific Dr. Hamish Stewart Staff Scientist, Analytical Instruments Group, Thermo Fisher Scientific Ann Thayer Contributing Editor, C&EN Media Group
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Wednesday, March 27, 2024
With a new generation of cloud HPC and AI tools, computational chemistry and materials science is scaling and accelerating R&D efforts that could address some of our world’s toughest challenges. While there are few concrete examples of computational discoveries that have been validated experimentally, a shift is finally starting to take place.    In this special session, Microsoft will share some of its latest updates, including how a collaboration with Pacific Northwest National Laboratory is demonstrating methods to accelerate scientific discovery for energy storage solutions. Together, the teams have been able to discover and synthesize a material that shows potential for resource-efficient batteries in less than nine months. We will explore how advancements in HPC and AI are accelerating the next frontier of scientific breakthroughs, in turn compressing the next 250 years of chemistry into the next 25.    Key Learning Objectives: Learn how cloud-based high-performance computing and artificial intelligence can scale and accelerate discovery in materials science.  Explore one of Microsoft’s latest computational discoveries that was accelerated using Azure Quantum Elements.  Find out how Microsoft collaborated with Pacific Northwest National Laboratory to discover and synthesize a material to advance sustainable energy-storage solutions.  Discover how industry innovators adopted Azure Quantum Elements to transform their research and development.  Who Should Attend: Computational Materials Scientists  R&D Leaders  Computational Chemists  Digitization Managers C-suite  Brought to you by: Speakers: Dr. Nathan Baker Azure Quantum Elements Product Leader, Microsoft Melissa O'Meara Forensic Science Consultant, C&EN Media Group
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