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DYH0310
New Contributor

2 questions about organic chemistry

1.In the process of nitrifying benzene with nitric acid,the use of HFIP can make the nitrification reaction condition milder

How could this work?

2.In the reaction of 2-chloropyrazine with thiophenol, the reaction did not occur if the solvent was isopropanol(ipr) ,wherean the produce was obtained in 94% yield whit HFIP(300K,12h)

How could this work???

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stephmayo
New Contributor

Re: 2 questions about organic chemistry

  1. HFIP in Organic Synthesis

    Hashim F. Motiwala, Ahlam M. Armaly, Jackson G. Cacioppo, Thomas C. Coombs, Kimberly R. K. Koehn, Verrill M. Norwood IV, and Jeffrey Aubé
    Chemical Reviews 2022 122 (15), 12544-12747
    DOI: 10.1021/acs.chemrev.1c00749

this article seems to explain the mechanisms 

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