1.In the process of nitrifying benzene with nitric acid,the use of HFIP can make the nitrification reaction condition milder
How could this work?
2.In the reaction of 2-chloropyrazine with thiophenol, the reaction did not occur if the solvent was isopropanol(ipr) ,wherean the produce was obtained in 94% yield whit HFIP(300K,12h)
How could this work???
this article seems to explain the mechanisms