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Decursin as potential antiepileptic drug

Decursin is a coumarin from The roots of Peucedanum ostruthium. Coumarins, such as decursinol and decursin, are known to be the major compounds of A. gigas. Angelica gigas roots have been widely used traditionally in Korean herbal medicine not only for the treatment of anaemia, but also as a sedative, an anodyne and a tonic. Studies have shown that decursin inhibits VEGF-mediated inner BRB breakdown through suppression of VEGFR-2 signaling pathway. And decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug.

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