6 Replies Latest reply on May 28, 2015 8:25 AM by Wayne Cook

    Mixing different powdered ingridients to form...

    Yoad Ben Yosef



      I was wondering, what is the best way to mix several, 3-6 different powdered ingridients, so the resulting formula will give consistent amounts of each ingridient.


      Im interested in this because I want to make my own "vitamin" complex, but I want to make a bulk because its tedious to measure miligrams each time I want to mix them, but still, if I mix the bulk how am I suppose to be sure that they were mixed so the ratio of each ingridient will be about the same as if i'd mix them seperatly? is there some process to this?


      thank you.



        • Re: Mixing different powdered ingridients to form...
          Milda Embuscado

          If you have a Hobart mixer, you can use this to blend several ingredients homogeneously.  Mix for about 4-5 minutes.  You can use a flat beater.  You have to have substantial amount in the bowl to be able to mix thoroughly.

          • Re: Mixing different powdered ingridients to form...
            Robert Pertuit

            Since it's for implied in vivo use, no procedural suggestions. Consider compatibility. Consider acceptable variation/deviation.

            • Re: Mixing different powdered ingridients to form...
              Wayne Cook

              There are many ways to blend dry solids.  As mentioned by others, it is critical to know if you need to "mill" or breakdown the particles to a smaller size.  If you just want a uniform mixture of several solids which do not interact,  a ribbon-blender will work.  If you need to breakdown the particles to a smaller size, you will need something more energetic.  On a lab scale, a blender or coffee mill works very well.

              With respect to a procedure, measuring the uniformity of a dry solids mixture is difficult.  Most manufacturers will sample the dry mixture at several different places in the container and analyze them separately.  If the analysis of all of the samples is the same (within specifications or statistic limits) you have some confidence that the mixture is uniform.  If not, you will need more blending.

              All of this presumes that these components do not interact.  Some solids will agglomerate or absorb moisture forming non-uniform particles.  You will have to determine what works experimentally.

              Many equipment manufacturers will gladly help you test you mixture for blending properties.  Their goal is to help you so you will buy their equipment but they can help.  You can find manufacturers on the internet.

              Good luck!