Advancements in Cross-Coupling Catalysis with MPhos, A Novel Tunable Ligand

ACS Webinars Hub Placeholder Image.png
Published on ‎06-15-2023 03:21 PM by | Updated on ‎06-15-2023 03:22 PM

Transition metal catalyzed cross-coupling reactions are one of the most important and widely used reactions in modern organic synthesis. In this presentation, you will learn about a newly developed class of phosphine ligands targeting a relatively underexplored type of cross-coupling reaction.  
MPhos is a novel class of ferrocene-based unsymmetrical ligands. Along with their corresponding PdCl2 pre-catalysts, these ligands are employed for a variety of Csp2-Csp3 couplings reactions such as Murahashi-Feringa, Kumada-Corriu, Negishi and Suzuki-Miyaura. Various substrates include “drug-like” molecules to demonstrate its potential applications in API synthesis. The details of the study will be discussed in the presentation. 
Key Learning Objectives:
  • Difficulties in Csp2-Csp3 Couplings 
  • Benefits of MPhos ligands and precatalysts
Who Should Attend:
  • Synthetic chemists interested in learning about a new class of cross-coupling catalysts
  • Medicinal chemists seeking additional ligands and catalysts for high-throughput screening

Brought to you by:




%7Bf0b317d8-eeb6-4cd2-a56d-0af2423979fd%7D_Speaker_100x100Thomas Colacot
R&D Fellow and Director of Global Technology Innovation, Life Science Business,

%7B2ca08302-9b4a-4f05-9567-32b5c3f9f223%7D_AnnThayer_100x100Ann Thayer
Contributing Editor,
C&EN Media Group

Event has ended
You can no longer attend this event.

Tue, Jul 18, 2023 11:00 AM EDT
Tue, Jul 18, 2023 12:00 PM EDT
<a href=''>Register</a>
Labels (2)
0 Kudos