Analyzing Protein Developability and Stability at High-Throughput
Published on 05-11-202303:21 PM by
a_borsuk| Updated on 05-11-202303:22 PM
Understanding the biophysical state, quality and properties of biopharmaceuticals is essential in product and process development. However, available material, time and resources are often limiting.
Dynamic light scattering (DLS) is an industry standard technique for protein formulation, particle sizing and stability studies. This webinar will illuminate how high-throughput DLS (HT-DLS), performed in low-volume microwell plates, is used to understand aggregation as well as colloidal and thermal stability of therapeutic protein candidates and formulations. Application examples include various studies of freeze-thaw, formulation buffer screening and thermal stability.
Key Learning Objectives:
Background and instrumentation for HT-DLS
How DLS is used to study aggregation under applied stresses
How DLS evaluates protein colloidal stability via second virial coefficient A2 and the diffusion interaction parameter kD.
Who Should Attend:
Biopharma product development scientists in need of automated methods for characterizing protein stability
Formulation lab managers seeking to improve productivity with high-throughput DLS instrumentation
Brought to you by:
Felix Gloge, Ph.D. Field Application Scientist, Wyatt Technology
Christian Sieg, Ph.D. Application Scientist, Wyatt Technology
Melissa O'Meara Forensic Science Consultant, C&EN Media Group