Approaches to Uncooperative Drugs in In Vitro Transporter Research

cancel
Showing results for 
Search instead for 
Did you mean: 

Approaches to Uncooperative Drugs in In Vitro Transporter Research

%7Bafd22d1b-40f1-40b7-9e2a-f1b7eddab301%7D_BioIVT-Drug-Transport-Resources
Published on ‎09-21-2023 11:14 AM by | Updated on ‎09-21-2023 11:15 AM

In vitro drug transporter data is critical for understanding drug-drug interaction potential, but this data is only useful if conclusions can be drawn. Researchers are confronted with practical challenges associated with compounds that are unstable, sticky or insoluble, resulting in convoluted or inconclusive results. 
 
Three interesting transporter case studies will be presented, each highlighting a creative solution to explore perplexing initial results and generate useful data, despite problematic physicochemical characteristics of the drugs involved. 
 
Key Learning Objectives:
  • Fundamental test system and platform limitations in drug transporter research 
  • Practical methodologies to account for nonspecific binding and instability in transporter studies 
  • Study designs with case studies 
Who Should Attend:
  • Research scientists and drug development leadership aiming for successful IND / NDA submission, needing to meet regulatory requests and expectations, desiring to formulate a development plan that mitigates risks of late-stage failure, or simply wanting to better understand the ADME properties and potential DDI risks of their compound.

Brought to you by:

%7Bbc4ed027-172b-434c-95dd-145b1e79f9e8%7D_BioIVT_4C_Logo

Speakers:

%7Bc4cd0523-5a6e-4484-a145-f933e163212e%7D_Speaker_100x100Joanna Barbara, PhD
ADME Research Site Head,
BioIVT



%7Bbcd52f97-76cf-4621-bdda-5677d2987616%7D_MelissaOmeara_croppedMelissa O'Meara
Forensic Science Consultant,
C&EN Media Group



Event has ended
You can no longer attend this event.

Start:
Tue, Oct 3, 2023 11:00 AM EDT
End:
Tue, Oct 3, 2023 12:00 PM EDT
<a href='https://connect.discoveracs.org/CENWebinar_BioIVT_10_3_23?partnerref=WebinarsHub'>Register</a>.
Labels (2)
0 Kudos
0 Comments