Probing Metabolite Utilization and Growth in Pathogenic Microbes

Published on ‎05-11-2022 11:30 AM by

A sub-class of pathogenic microbes exhibit drastically increased biomass accumulation when supplemented with short chain fatty acids (SFCAs). This phenomenon was probed via untargeted stable isotope labeling metabolomic studies leveraging Thermo Scientific™ Compound Discoverer™ software. Metabolites presenting fold changes as well as downstream isotopic enrichment from a 13C2 acetate substrate were used to inform on this unusual phenomenon and increase our understanding of the microbe's pathogenic mechanism.
Key Learning Objectives:
  • Understand how to study biological metabolism with liquid chromatography-mass spectrometry
  • Learn how to perform untargeted stable isotope labeling experiments
  • See advanced tools for analyzing and reporting untargeted stable isotope labeling data
Who Should Attend:
  • Scientists interested in metabolomics and stable isotope labeling
  • Analytical chemists
  • Scientists interested in studying biological processes


Brought to you by:



Juan Moises Sanchez
Chan Zuckerberg Biohub at Stanford University

%7Bbcd52f97-76cf-4621-bdda-5677d2987616%7D_MelissaOmeara_croppedMelissa O'Meara
Forensic Science Consultant,
C&EN Media Group

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