Real-Time Analysis of Product Attributes in Downstream Processing of Viral Vectors

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Published on ‎02-14-2023 04:11 PM by | Updated on ‎02-24-2023 01:33 PM

One of the key challenges during process development and production of biologics is the timely determination of essential product attributes. Rapid feedback of product-relevant characteristics simplifies and accelerates process development and scale-up, then helps ensure product yield and quality during full-scale manufacturing.
 
We present the use of real-time multi-angle light scattering (RT-MALS) as a process analytical technology to optimize process development of viral vectors. RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles. The application of RT-MALS in downstream processing of viral vectors is shown and discussed. 
 
Key Learning Objectives:
  • Introduction to real-time MALS (RT-MALS) 
  • How RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles
  • Application of RT-MALS for viral vectors  
Who Should Attend:
  • Bio/pharmaceutical scientists responsible for process analytical technology (PAT), downstream processing, process development and production of biologics
  • Process engineers seeking solutions for monitoring viral vectors or nanoparticle production processes

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%7B2763403e-5a3b-4a75-a783-eb519daca017%7D_%7B598014de-da95-4af6-b4c6-8650f9151f4d%7D_Wyatt-Technology-Logo

 

Speakers:

%7B8cf61131-3d10-43dc-9908-05418eae0f76%7D_Clara_100100Dr. Clara Pérez Peinado
Senior Scientist, Biophysics and Process Analytics Team,
Janssen Vaccines & Prevention B.V



%7B74895123-4bf9-43a0-be81-733afb033109%7D_Some_100x100Dan Some, Ph.D.
Principal Scientist,
Wyatt Technology Corp.



%7Bcdccb62d-4f94-40ad-b78d-37a1fa5cc717%7D__kellymcsweeney_croppedKelly McSweeney
Contributing Editor,
C&EN Media Group



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Start:
Tue, Mar 7, 2023 11:00 AM EST
End:
Tue, Mar 7, 2023 12:00 PM EST
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