Real-Time Analysis of Product Attributes in Downstream Processing of Viral Vectors
One of the key challenges during process development and production of biologics is the timely determination of essential product attributes. Rapid feedback of product-relevant characteristics simplifies and accelerates process development and scale-up, then helps ensure product yield and quality during full-scale manufacturing.
We present the use of real-time multi-angle light scattering (RT-MALS) as a process analytical technology to optimize process development of viral vectors. RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles. The application of RT-MALS in downstream processing of viral vectors is shown and discussed.
Key Learning Objectives:
- Introduction to real-time MALS (RT-MALS)
- How RT-MALS determines the biophysical properties size, molar mass and concentration of virions or nanoparticles
- Application of RT-MALS for viral vectors
Who Should Attend:
- Bio/pharmaceutical scientists responsible for process analytical technology (PAT), downstream processing, process development and production of biologics
- Process engineers seeking solutions for monitoring viral vectors or nanoparticle production processes
Brought to you by:
Speakers:
Senior Scientist, Biophysics and Process Analytics Team,
Janssen Vaccines & Prevention B.V
Principal Scientist,
Wyatt Technology Corp.
Contributing Editor,
C&EN Media Group
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Start:
Tue, Mar 7, 2023 11:00 AM EST
End:
Tue, Mar 7, 2023 12:00 PM EST
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