Advancements in Cross-Coupling Catalysis with MPhos, A Novel Tunable Ligand
Transition metal catalyzed cross-coupling reactions are one of the most important and widely used reactions in modern organic synthesis. In this presentation, you will learn about a newly developed class of phosphine ligands targeting a relatively underexplored type of cross-coupling reaction.
MPhos is a novel class of ferrocene-based unsymmetrical ligands. Along with their corresponding PdCl2 pre-catalysts, these ligands are employed for a variety of Csp2-Csp3 couplings reactions such as Murahashi-Feringa, Kumada-Corriu, Negishi and Suzuki-Miyaura. Various substrates include “drug-like” molecules to demonstrate its potential applications in API synthesis. The details of the study will be discussed in the presentation.
Key Learning Objectives:
- Difficulties in Csp2-Csp3 Couplings
- Benefits of MPhos ligands and precatalysts
Who Should Attend:
- Synthetic chemists interested in learning about a new class of cross-coupling catalysts
- Medicinal chemists seeking additional ligands and catalysts for high-throughput screening
Brought to you by:
Speakers:
R&D Fellow and Director of Global Technology Innovation, Life Science Business,
MilliporeSigma
Contributing Editor,
C&EN Media Group
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Start:
Tue, Jul 18, 2023 11:00 AM EDT
End:
Tue, Jul 18, 2023 12:00 PM EDT
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